Endocrine Abstracts

Introduction: ALS is a neurodegenerative disease with a high prevalence of malnutrition. Nutritional diagnosis is important because of its prognostic implication.Objective: To determine the clinical and morphofunctional characteristics in a series of patients with ALS.Materials and methods: Cross-sectional descriptive study of patients seen at the multidisciplinary ALS clinic of the Hospital Puerta del Mar (Cádiz).<p class...

Introduction and Objectives: Continuous glucose monitoring (CGM) has demonstrated benefits in the prevention of hypoglycemia in patients with type 1 diabetes mellitus (DM1) vs flash monitoring (CGM). Our aim was to analyze the clinical characteristics, indication and glucometric changes in patients using MFG after CGM implantation.Material and methods: Retrospective observational study of 13 patients under follow-up for DM1 in Endocrinology consultations...

Objective: Endogenous cushing syndrome (ECS) is a complex and rare disease. After treatment, 50% of cases have recurrence. The objective is to evaluate the prevalence of recurrences in patients diagnosed of ECS and its predictive factors.Materials and Methods: Analytical retrospective observational study with 19 ECS diagnoses cases followed-up from January 1999 to December 2023. Demographic (sex, age), clinical (cause, face plethora, fragile capillary, r...

Despite being the most successful definitive treatment for GD and offering the best response in terms of quality of life, thyroidectomy is rarely performed worldwide. Few studies evaluate its complication rate and potential prognostic factors for complications. We report our last ten years’ experience. Incidence of temporary and permanent hypoparathyroidism, temporary and permanent recurrent laryngeal nerve (RLN) injury and incidental malignancy were recorded, looking for...

Metabolic-associated fatty liver disease (MAFLD) is a growing cause of hepatocellular carcinoma (HCC), but the molecular mechanisms associated with the pathological progression from MAFLD to HCC are still to be fully elucidated. The genomic and transcriptomic profile of HCC samples have been widely described; however, the proteomic landscape of MAFLD-derived HCC samples is mostly unknown. Here, we sought to perform the first quantitative proteomic analysis of HCC samples from ...

Corticotrope cells give arise to utmost aggressive and to very rare pituitary neoplasias, including pituitary carcinomas, Crooke’s cell adenomas (CCA), clinically non-functioning silent corticotrope adenomas (SCA) and the Cushing-provoking pituitary adenomas (CD). The molecular etiopathogenesis of these tumors are still poorly understood. Therefore, we carried out whole exome sequencing to better understand the full genomic landscape single nucleotide variants and copy nu...

Background: Sarcopenic obesity(SO) is an entity characterized by excess fat mass(FM) and low muscle mass (LMM) and function. Excess FM itself can lead to loss of muscle mass and function at any age. The combination of obesity and sarcopenia is a proven risk factor for frailty, comorbidities and mortality. New diagnostic criteria have been developed for this entity.Aims: To assess the prevalence and severity of SO with different indices by DXA, in a group...

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

Aim: Bariatric surgery (BS) modifies body composition. The aim of the study was to establish the first step toward the introduction of the ultrasound (US) and bioelectrical impedance analysis (BIA) in the evaluation of body composition before and after BS. In addition, as obesity was shown to be related to global cognitive decline, we aim to determine possible changes in cognitive test before and after BS.Material and Methods: a prospective pilot study o...

Metabolic associated fatty liver disease (MAFLD) is rapidly becoming a major aetiology for the development of hepatocellular carcinoma (HCC, the most common liver cancer) in the context of chronic liver disease. Current therapeutical options for MAFLD (dietetic/lifestyle intervention and/or pharmacological approaches) are still insufficient and the cellular and molecular mechanisms underlying this disease are yet to be fully understood. Our group previously reported that the n...